The HEDGE Study Update

The Hypermobile Ehlers-Danlos Genetic Evaluation (HEDGE) study was initiated by The Ehlers-Danlos Society to examine the genes of over 1000 particpants around the world who have hEDS or HSD (Hypermobility Spectrum Disorders). It is the most extensive study involving over 85 counties with an aim to find a genetic cause of hEDS.

An October 2025 Update included the following findings:

• The MTHFR mutation did not prove to be linked to hEDS.
• TXNB variants were found to increase the risk for hEDS 3-5x compared to the general population; however this accounted for only 1% of participants.
• The recently linked KLK15 variants were shown to be just as common in the participants as controls; however, it could still lead to symptoms in some people.